GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2275426 | 1 | rs61783200 | chr1:46297403 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.07 | 5.44E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61783200 | chr1:46297403 | MMACHC | chr1:45965856-45976737:+ | -0.19 | -4.28 | 2.24E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61783200 | chr1:46297403 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.34 | 7.9E-16 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61783220 | chr1:46335312 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.1 | 7.22E-22 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61783220 | chr1:46335312 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.05 | 5.93E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61783220 | chr1:46335312 | MMACHC | chr1:45965856-45976737:+ | -0.2 | -4.4 | 1.34E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61783220 | chr1:46335312 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.53 | 1.99E-16 | Body mass index |
| THCA | cis | rs4409675 | 1 | rs61789695 | chr1:28255693 | RPA2 | chr1:28218049-28241236:- | 0.45 | 8.92 | 9.73E-18 | Corneal astigmatism |
| THCA | cis | rs11723261 | 1 | rs61792114 | chr4:289139 | ZNF718 | chr4:53272-156488:+ | 0.52 | 10.23 | 2.47E-22 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs11723261 | 1 | rs61792116 | chr4:301077 | ZNF718 | chr4:53272-156488:+ | 0.5 | 9.18 | 1.25E-18 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs11723261 | 1 | rs61794996 | chr4:209328 | ZNF718 | chr4:53272-156488:+ | 0.51 | 9.44 | 1.68E-19 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs11723261 | 1 | rs61794996 | chr4:209328 | ZNF732 | chr4:259482-299263:- | -0.24 | -3.41 | 0.000698 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs11723261 | 1 | rs61794997 | chr4:222103 | ZNF718 | chr4:53272-156488:+ | 0.51 | 9.54 | 7.09E-20 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs11723261 | 1 | rs61795001 | chr4:242057 | ZNF718 | chr4:53272-156488:+ | 0.51 | 9.49 | 1.14E-19 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs11723261 | 1 | rs61795002 | chr4:242797 | ZNF718 | chr4:53272-156488:+ | 0.51 | 9.49 | 1.14E-19 | Immune response to smallpox vaccine (IL-6) |